No. You need either CFW, HEN, or a hardware ODE (like the now-rare Cobra ODE). Without modification, the PS3 only boots signed discs.
This is where the PS3 differs from almost every other console. You cannot just drag and drop a file and expect it to work. The PS3 has three distinct formats, and confusing them ruins the install experience. ps3 roms archive install
These are digital store versions. You need both the .pkg (the game) and the .rap (the license file) to make them work. 2. Preparing Your Hardware (The "Softmod") No. You need either CFW
If you use ISOs on a real console, Webman Mod is highly recommended for mounting them directly from your XMB menu without opening extra apps. ps3 roms archive install