Bringhurst famously states, "Choose faces that suit the paper and the ink, or the screen and the pixel, and that suit the text."

The book often uses Minion Pro for body text and Scala Sans for captions. If you don't have these installed, Word will substitute them, drastically changing the look.

To maintain the complex layouts and specific font styles Bringhurst describes, use high-fidelity converters: Adobe Acrobat Online

If you do not own the book, buy it. The PDF often comes free with purchase from the publisher (Editorial Gustavo Gili).

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The Elements of Typographic Style: Robert Bringhurst - Amazon.com