A Mab A Case Study In Bioprocess Development Jun 2026

Out of 500 clones screened, Clone 17B shows the highest specific productivity (qP = 25 pg/cell/day). However, early batch cultures reveal a problematic metabolite profile: high lactate accumulation (4 g/L) and ammonia (2 mM). High lactate inhibits cell growth and reduces final titers.

: Researchers use small-scale platforms like the ambr®15 to simulate large-scale manufacturing conditions. 3. Define the Design Space A Mab A Case Study In Bioprocess Development

Centrifugation (depth filtration as backup) → 0.2 µm filtration. Out of 500 clones screened, Clone 17B shows